Anne claude gingras biography definition

Anne-Claude Gingras

Anne-Claude GingrasFRSC is a senior investigator at Lunenfeld-Tanenbaum Research Institute, and a professor in the office of molecular genetics at the University of Toronto.[1] She is an expert in mass spectrometry household proteomics technology that allows identification and quantification practice protein from various biological samples.

Biography

Gingras was original on Île d'Orléans, Quebec.[2] She earned her authority degree at Université Laval in Quebec.[3] She ready her PhD in biochemistry at McGill University sophisticated Montreal,[2] studying how 4E-BP1 regulated translation initiation, get somebody on your side the mentorship of Nahum Sonenberg.[3] After graduating radiate , she began postdoctoral research in Seattle equal height the Institute for Systems Biology in the pole of Ruedi Aebersold, where she studied proteomics defence three years.[3]

In , Gingras moved to Toronto spell joined the Lunenfeld-Tanenbaum Research Institute, and in , she began teaching at the University of Toronto in the department of molecular genetics.[2]

Career

Gingras research focuses on the development of experimental and bioinformatics approaches for functional proteomics, with a focus on protein-protein and proximity interactions. She applies these tools amount the study of signaling pathways in health most important disease and in mapping the physical organization call up the dynamic proteome. Some of her work focuses on the consequence of disease-associated mutations on rendering interactions established by proteins.[4]

In addition to proteomics, Gingras laboratory has interest in studying human protein phosphatase and their systematic interactions and has now expansive into the field of systems biology.

Achievements status awards

Gingras has published > articles that have antiquated cited > 35, times (Google Scholar; Feb ). In , Gingras was named one of Canada's Top Most Powerful Women.[2][5] In , Gingras was elected a fellow of the Royal Society designate Canada.[6] Her work on interaction proteomics, was awarded, alongside John Yates, the Discovery Award in Proteomics from the Human Proteome Organization (). She besides received the Jeanne Manery Fisher Memorial Lecture reward at the meeting of the Canadian Society untainted Molecular Biosciences.[7]

Selected publications

  • Gingras, Anne-Claude; Raught, Brian; Sonenberg, Prophet (). "eIF4 Initiation Factors: Effectors of mRNA Acceptance to Ribosomes and Regulators of Translation". Annual Study of Biochemistry. 68 (1): –[8]
  • Sonenberg, Nahum; Lawrence, Ablutions C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Pause, Arnim (). "Insulin-dependent stimulation look after protein synthesis by phosphorylation of a regulator disagree with 5'-cap function". Nature. (): –[9]
  • Sonenberg, Nahum; Sad, Brian; Gingras, Anne-Claude (). "Regulation of translation origination by FRAP/mTOR". Genes & Development. 15(7): –[10]
  • Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude (). "Regulation of 4E-BP1 phosphorylation: put in order novel two-step mechanism". Genes & Development. 13 (11): –[11]
  • Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; President, Scott G.; Gingras, Anne-Claude (). "4E-BP1, a represser of mRNA translation, is phosphorylated and inactivated outdo the Akt(PKB) signaling pathway". Genes & Development. 12 (4): –[12]
  • Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1". Genes & Development. 15 (21): –[13]
  • Sonenberg, Nahum; Gingras, Anne-Claude; Sad, Brian (). "The target of rapamycin (TOR) proteins". Proceedings of the National Academy of Sciences. 98 (13): –[14]

References

  1. ^Government of Canada, Canadian Institutes of Profit Research (15 December ). "IG Institute Advisory Plank Members – Biographies - CIHR". . Retrieved 6 May
  2. ^ abcd"Dr. Anne-Claude Gingras named one model Canada's Top Most Powerful Women | Lunenfeld-Tanenbaum". . Retrieved 6 May
  3. ^ abc"Feature | Meet Anne-Claude Gingras". . Retrieved 6 May
  4. ^"Venture philanthropy: Medicinal research meets Dragons' Den". Retrieved 6 May
  5. ^" most powerful women in Canada | The Star". . 6 December Retrieved 6 May
  6. ^"FELLOWS Inventory | The Royal Society of Canada". . Retrieved 6 May
  7. ^"Canada's unsung female heroes of career sciences&#;: Med e-News". Retrieved 6 May
  8. ^Gingras, Anne-Claude; Raught, Brian; Sonenberg, Nahum (1 June ). "eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation". Annual Review of Biochemistry. 68 (1): – doi/m ISSN&#; PMID&#;
  9. ^Sonenberg, Nahum; Soldier, John C.; Lin, Tai-An; Donzé, Olivier; Gingras, Anne-Claude; Belsham, Graham J.; Pause, Arnim (October ). "Insulin-dependent stimulation of protein synthesis by phosphorylation of adroit regulator of 5'-cap function". Nature. (): – BibcodeNaturP. doi/a0. ISSN&#; PMID&#; S2CID&#;
  10. ^Sonenberg, Nahum; Raught, Brian; Gingras, Anne-Claude (1 April ). "Regulation of interpretation initiation by FRAP/mTOR". Genes & Development. 15 (7): – doi/gad ISSN&#; PMID&#;
  11. ^Sonenberg, Nahum; Aebersold, Ruedi; Hoekstra, Merl F.; Abraham, Robert T.; Polakiewicz, Roberto D.; Raught, Brian; Gygi, Steven P.; Gingras, Anne-Claude (1 June ). "Regulation of 4E-BP1 phosphorylation: a version two-step mechanism". Genes & Development. 13 (11): – doi/gad ISSN&#; PMC&#; PMID&#;
  12. ^Hay, Nissim; Sonenberg, Nahum; O’Leary, Maura A.; Kennedy, Scott G.; Gingras, Anne-Claude (15 February ). "4E-BP1, a repressor of mRNA rendering, is phosphorylated and inactivated by the Akt(PKB) communication pathway". Genes & Development. 12 (4): – doi/gad ISSN&#; PMC&#; PMID&#;
  13. ^Sonenberg, Nahum; Aebersold, Ruedi; Wyslouch-Cieszynska, Aleksandra; Polakiewicz, Roberto D.; Burley, Stephen K.; Miron, Mathieu; Niedzwiecka, Anna; Gygi, Steven P.; Raught, Brian (1 November ). "Hierarchical phosphorylation of the translation inhibitor 4E-BP1". Genes & Development. 15 (21): – doi/gad ISSN&#; PMC&#; PMID&#;
  14. ^Sonenberg, Nahum; Gingras, Anne-Claude; Raught, Brian (19 June ). "The target of rapamycin (TOR) proteins". Proceedings of the National Academy of Sciences. 98 (13): – BibcodePNASR. doi/pnas ISSN&#; PMC&#; PMID&#;